4RTNI/4RTNI-2

The Four Repeat Tauopathy Neuroimaging Initiative study was made possible by National Institute on Aging grant 2R01AG038791. We thank the staff and investigators of the study as well as the participants and their families, whose help and participation made this work possible.

90+ STUDY

The 90+ Study receives support through a National Institute on Aging (NIA) grant R01AG21055. We thank the staff and investigators of the study as well as the participants and their families, whose help and participation made this work possible.

AA Genetics

The AA Genetics Study was made possible by Grant Number R01 AG028786 from the National Institute on Aging (NIA). We thank the staff and investigators of the study as well as the participants and their families, whose help and participation made this work possible.

ABC-DS

The Alzheimer’s Biomarkers Consortium – Down Syndrome (ABC-DS) project is a longitudinal study of cognition and blood based, genetic and imaging biomarkers of Alzheimer’s Disease. This study is funded by the National Institute on Aging (NIA) grants U01AG051406 and U01AG051412 and the National Institute for Child Health and Human Development (NICHD). We thank the ABC-DS study participants and the ABC-DS research and support staff for their contributions to this study.

ADRC

Samples are contributed by the NIA-funded ADRCs: P30 AG066506 (PI Glenn Smith, PhD/David Loewenstein, PhD), P30 AG072980 (PI Eric Reiman, MD), P30 AG072978 (PI Ann McKee, MD), P30 AG072959 (PI James Leverenz, MD), P20 AG068053 (PI Justin Miller, PhD), P30 AG066462 (PI Scott Small, MD), P30 AG072958 (PI Heather Whitson, MD/Gwenn Garden, MD, PhD), P30 AG066511 (PI Allan Levey, MD, PhD), P30 AG072976 (PI Andrew Saykin, PsyD), P30 AG066507 (PI Marilyn Albert, PhD), P30 AG062421 (PI Bradley Hyman, MD, PhD), P30 AG062677 (PI Ronald Petersen, MD, PhD), P30 AG066514 (PI Mary Sano, PhD), P30 AG066512 (PI Thomas Wisniewski, MD), P30 AG072977 (PI Robert Vassar, PhD), P30 AG066518 (PI Lisa Silbert, MD, MCR/Miranda Lim, MD), P30 AG072975 (PI Julie Schneider, MD, MS), P30 AG066546 (PI Sudha Seshadri, MD, DM/Gladys Maestra, MD, PhD), P30 AG066515 (PI Victor Henderson, MD, MS/Kati Andreasson, MD), P20 AG068024 (PI Erik Roberson, MD, PhD), P30 AG072972 (PI Charles DeCarli, MD), P30 AG066519 (PI Frank LaFerla, PhD/Joshua Grill, PhD), P30 AG062429 (PI James Brewer, MD, PhD), P30 AG062422 (PI Gil Rabinovici, MD), P30 AG072973 (PI Russell Swerdlow, MD), P30 AG072946 (PI Linda Van Eldik, PhD), P30 AG072931 (PI Henry Paulson, MD, PhD), P30 AG072979 (PI David A Wolk, MD), P30 AG066468 (PI Oscar Lopez, MD/Julia Kofler, MD), P30 AG066530 (PI Helena Chui, MD/Arthur Toga, PhD), P30 AG012300 (PI Roger Rosenberg, MD), P30 AG066509 (PI Thomas Grabowski, MD), P30 AG062715 (PI Sanjay Asthana, MD, FRCP), P20 AG068077 (PI Gary Rosenberg, MD), P20 AG068082 (PI Angela Jefferson, PhD), P30 AG072947 (PI Suzanne Craft, PhD), P30 AG066444 (PI John Morris, MD), P30 AG066508 (PI Christopher van Dyck, MD/Stephen Strittmatter, MD, PhD).

ADGC

The Alzheimer's Disease Genetics Consortium supported the collection of samples used in this study through National Institute on Aging (NIA) grants U01AG032984 and RC2AG036528.

AGMP

Samples collected by the Alzheimer Gut Microbiome Project (AGMP) were supported by the National Institute On Aging of the National Institutes of Health under Award Number U19AG063744. (mPIs - Drs. Rima Kaddurah-Daouk, Rob Knight, and Sarkis Mazmanian)

ALLFTD

The ARTFL-LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) study receives support through a National Institute of Aging (NIA) and National Institute of Neurological Disorders and Stroke (NINDS) grant U19AG063911. We thank the staff and investigators of the study as well as the participants and their families, whose help and participation made this work possible.

ARTFL/LEFFTDS iPSCs

iPSCs: The Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) and Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS) Studies were made possible through the support of the U.S Department of Health and Human Services (DHHS), the National Institute on Aging (NIA), the National Institute of Neurological Disorders and Stroke (NINDS) and the National Center for Advancing Translational Sciences (NCATS) grants: U54NS092089 and U01AG045390. We thank the staff and investigators of the study as well as the participants and their families, whose help and participation made this work possible. In addition, we acknowledge Drs. Kathryn Bowles and Alison Goate at the Icahn School of Medicine at Mount Sinai for their work in generating the CRISPR-edited iPSC lines. This work was funded by the Rainwater Charitable Foundation, the Association for Frontotemporal Dementia and the BrightFocus Foundation (#A21007144F)

ANGI

The collection of the Amyloid Neuroimaging and Genetics Initiative (ANGI) samples was supported by a grant from the Alzheimer’s Association (ANGI/IDEAS-17-497186). We thank the Alzheimer’s Association for their support and the ANGI study participants for their contribution to the study. We would also like to acknowledge the Imaging Dementia – Evidence for Amyloid Scanning Study (iDEAS) from whom amyloid imaging and other clinical data were obtained.

API-ADAD

The API Colombia trial was supported by funding from the National Institute on Aging (1RF1AG041705, 5R01AG055444), part of the National Institutes of Health, Banner Alzheimer’s Foundation and Genentech/Roche.

DIAN

The DIAN Study receives support through a National Institute on Aging (NIA) grant U19AG032438. We thank the staff and investigators of the study as well as the participants and their families, whose help and participation made this work possible.

DMDC

The Duke Memory Disorders Clinic Biorepository is a one time collection of blood and patient data donated by the patient population in the Duke Memory Disorders Clinic with a variety of neurodegenerative conditions.

It is made possible by the Department of Neurology at Duke University.

GEMS

This publication was made possible by Grant Number U01 AT000162 from the National Center for Complementary and Alternative Medicine, National Institutes of Health.

GENERATION STUDY

The Generation Program was supported by Novartis Pharma AG, Basel, Switzerland and Amgen, Thousand Oaks, CA, USA, in collaboration with the Banner Alzheimer’s Institute located in Phoenix, AZ, USA. Generation Study 1 was supported by funding from the National Institute on Aging (UF1 AG046150), part of the National Institutes of Health, as well as the Alzheimer’s Association, FBRI, GHR Foundation and Banner Alzheimer’s Foundation. We thank the staff and investigators of the studies as well as the participants and their study partners, whose help and participation made this work possible.

GIFT

Samples from the Genetic Investigation of Frontotemporal Dementia (GIFT) study, which were collected as a collaborative effort of 6 ADRCs (UCSF, UCLA, UCD, UCI, USC, Emory University) funded by the NIA (R01AG26938; PIs Geschwind/Coppola) and banked with the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD), which receives government support under a cooperative agreement grant (U24 AG021886) awarded by the National Institute on Aging (NIA), were used in this study. We thank contributors, including the Alzheimer’s Disease Centers who collected samples used in this study, as well as patients and their families, whose help and participation made this work possible

HALS

Funding for this work was provided by NIH grant: R01 AGO69265.

INDIANAPOLIS-IBADAN STUDY

The Indianapolis-Ibadan dementia project is a 20 year comparative community based epidemiological study of the prevalence, incidence and risk factors for AD and dementia in populations of African origin, elderly African Americans in Indianapolis, Indiana and Yoruba in Ibadan, Nigeria. It was supported from 1991-2012 by NIH grants RO1 AG09956 and P30 AG 10133. We would like to take this opportunity to thank the many faculty and staff of the Universities of Ibadan and Indiana Medical School for their involvement as well as the 4000 plus elderly participants at each of the sites.

iPSC INITIATIVE

Samples and associated data are contributed by the National Institute on Aging (NIA) grant:

• P50 AG016573 (PI Frank LaFerla, PhD)
• 1 RF1 AG048083-01 (PI Lawrence Goldstein, PhD)
• P50 AG047366 (PI Victor Henderson, MD, MS)
• P50 AG005134 (PI Bradley Hyman, MD, PhD)
• R56 AG057478 (PI Suman Jayadev, MD)
• R01 AG062148 (PI Jessica Young, PhD)
• NIH NIEHS R01 ES031401 (Aaron Bowman, PhD, Jason Meyer, PhD)
• P30 AG062715 (Sanjay Asthana, MD)

We thank the staff and investigators of the study as well as the participants and families, whose help and participation is invaluable to this research effort.

LEADS

The Longitudinal Early-onset Alzheimer’s Disease Study is a longitudinal multi-site study designed to look at disease progression in adults with early-onset AD. Recruitment includes cognitively impaired and cognitively normal participants. This study is funded by NIA grants (R56 AG057195) and (U01 AG057195). We would like to thank the LEADS study participants and the LEADS research and support staff for their contributions to this study.

LIFE-DSR

The Down Syndrome Clinical Trials Network (DS-CTN) Study of Alzheimer’s Disease in Down Syndrome, Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) was a longitudinal study, collecting measures of change in cognition, function, behavior, and health status in adults with Down syndrome. Imaging and blood samples were collected for the development of plasma AD biomarkers useful in the DS population. This study was funded by LuMind IDSC Foundation with support from philanthropy, Alana Foundation, Merck, Eli Lilly, AbbVie and Alkermes. We are tremendously grateful to the study participants and their families, and the LIFE-DSR research and support staff for their contributions to LIFE-DSR.

NAPS/NAPS2

The North American Prodromal Synucleinopathy Consortium for REM Sleep Behavior Disorder and North American Prodromal Synucleinopathy Consortium for RBD, Stage 2 (NAPS2) receives support through the National Institute of Health (NIH) grants R34 AG056639 and U19AG071754. We thank the participants in the NAPS/NAPS2 Consortium for their invaluable contributions as well as the support staff at each of the member sites for their assistance.

NCRAD

Samples from the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD), which receives government support under a cooperative agreement grant (U24 AG021886) awarded by the National Institute on Aging (NIA), were used in this study. We thank contributors who collected samples used in this study, as well as patients and their families, whose help and participation made this work possible.

NIA-LOAD/NIA-AD-FBS

The NIA-LOAD National Institute on Aging Alzheimer’s Disease Family Based Study (NIA-AD FBS) supported the collection of samples used in this study through National Institute on Aging (NIA) grants U24AG026395 and R01AG041797. We thank contributors, including the Alzheimer’s Disease Centers who collected samples used in this study, as well as patients and their families, whose help and participation made this work possible.

SAL-AD

A Phase 1b, 12-Month, Randomized, Double Blind, Placebo-Controlled Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of Salsalate in Patients with Mild to Moderate Alzheimer’s Disease (UC-SAL-AD-001); NCT03277573. We thank the staff and investigators of the study as well as the participants and their families, whose help and participation made this work possible.

T2 Protect AD

A Phase 2 Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Efficacy and Safety of BHV-4157 in Patients with Mild to Moderate Alzheimer’s Disease receives support through Biohaven Pharmaceuticals, Inc. We thank the staff and investigators of the study as well as the participants and their families, whose help and participation made this work possible.

VIVAMIND STUDY

VIVAMIND STUDY: The Seamless Phase 2A-B Randomized Double Blind Placebo Conrolled Trial to Evaluate the Efficacy and Safety of PQ 912 in Patients with Early Alzheimer’s Disease (VIVA-MIND Study) was made possible through the support of the National Institute on Aging (NIA) under grant R01AG061146 and Vivoryan Therapeutics, N.V. We appreciate the staff, investigators, participants and their families for helping the VIVA-MIND trial meet milestones in Alzheimer’s disease research.

WRAP

This research was supported by National Institutes of Health awards RF1 AG027161, and Clinical and Translational Science Award (CTSA) program, through the NIH National Center for Advancing Translational Sciences (NCATS), grant UL1TR002373; Portions of this research were supported by resources at the Wisconsin Alzheimer’s Institute and the Geriatric Research Education and Clinical Center of the William S. Middleton Memorial Veterans Hospital, Madison, WI. We gratefully acknowledge the WRAP study team who have carefully acquired the longitudinal data, and the WRAP participants who make this research possible.