Wisconsin Registry for Alzheimer’s Prevention (WRAP)
WRAP is an observational longitudinal cohort study. The cohort includes persons at risk for AD due to parental family history and persons without such history. Participants are followed at regular intervals (approximately 2 years apart) with detailed in-person or telephone assessments, questionnaires, and bio-fluid collection. Persons will remain in the study until conversion to dementia, until other stopping rules apply, or until age 85.
WRAP is designed to characterize cognitive changes and identify predictive biomarkers, health and lifestyle features that confer risk and resilience to Alzheimer’s Disease (AD).
Study Participants
The WRAP study began in 2001 and will recruit up to 1900 participants who are healthy non-demented middle-aged adults age 40 to 65 at baseline with or without a parental family history of AD. Participants are recruited throughout Wisconsin at sites in Madison, Milwaukee and La Crosse.
Available Data
The comprehensive data set for WRAP includes item-level data from medical, functional, and neuropsychological evaluations, as well as interviews and questionnaires. Questionnaires include information about demographics, past medical history, current health, family history of dementing disorders, risk factors for AD (e.g., head trauma), lifestyle (e.g., exercise, diet, smoking), memory functioning, mental activities, cancer history, sleep hygiene, current and life stressors, social support, depressive symptoms, and prescribed and OTC medications. A Work History and Family Background questionnaire is also completed by each WRAP participant.
A fixed minimal dataset may be requested through WRAP; use must conform to WRAP Resource Request and Data Sharing policies.
There is a subset of WRAP participants with MRI and PET imaging data, also available for request and bound to the same policies.
Available Biospecimens
Genomic DNA, Whole Blood, Plasma, Serum, PBMCs, and CSF are available from subsets of our cohort.
WRAP collects longitudinal biospecimens at each study visit.
All subjects are asked to provide CSF and imaging but it is not required. All biospecimen requests undergo a formal review by the WRAP Executive Committee. Reviews are conducted on the 3rd Wednesday of every month. Requests must be received by the 2nd Wednesday of the month to be considered. Submissions received after that date will be brought to the subsequent meeting.